Symbol
Name
ID

Tnfsf11
tumor necrosis factor (ligand) superfamily, member 11
MGI:1100089

Phenotype annotations related to hematopoietic system

*	Aspects of the system are reported to show a normal phenotype.
	Darker colors indicate more annotations

Human Phenotypes	Pancytopenia	Anemia	Thrombocytopenia	Extramedullary hematopoiesis	Hepatosplenomegaly
Disease(s) Associated with TNFSF11
autosomal recessive osteopetrosis 2

Mouse Phenotypes

hematopoietic system phenotype

abnormal thymus cell ratio

abnormal thymus epithelium morphology

enlarged thymus medulla

small thymus medulla

decreased thymus weight

thymus hypoplasia

enlarged spleen

increased spleen weight

decreased immature B cell number

abnormal pro-B cell differentiation

arrested T cell differentiation

extramedullary hematopoiesis

macrocytic anemia

decreased bone marrow cell number

decreased Langerhans cell number

decreased mature B cell number

decreased osteoclast cell number

increased osteoclast cell number

abnormal osteoclast morphology

abnormal osteoclast cell number

abnormal spleen morphology

increased spleen red pulp amount

abnormal spleen B cell follicle morphology

abnormal spleen marginal zone morphology

decreased spleen white pulp amount

abnormal splenic cell ratio

Availability

Mouse Genotype

Tnfsf11^tles/Tnfsf11^tles

Tnfsf11^tm1.2Htaka/Tnfsf11^tm1.2Htaka

Tnfsf11^tm1Pngr/Tnfsf11^tm1Pngr

Tnfsf11^tm1Ywc/Tnfsf11^tm1Ywc

Tnfsf11^tles/Tnfsf11^tm1Pngr

Tnfsf11^tm1.2Htaka/Tnfsf11⁺

Tg(APCS-Tnfsf11*)#aKhs/0

Tnfsf11^tm1.1Caob/Tnfsf11^tm1.1Caob
Tg(Dmp1-cre)1Jqfe/0 (conditional)

Tnfsf11^tm1.1Caob/Tnfsf11^tm1.1Caob
Tg(Prrx1-cre)1Cjt/0 (conditional)

Tnfsf11^tm1.1Htaka/Tnfsf11^tm1.2Htaka
Tg(Dmp1-cre)1Jqfe/0 (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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